Royal Air Force Typhoon jets have operated alongside French aircraft in a combined operation targeting an subterranean weapons facility in Syrian territory employed by the IS group, according to the British defence ministry.
The location, pinpointed through surveillance, was believed to be housing weapons and explosive materials, the release indicated, and was located in mountainous terrain just above Palmyra in the heart of Syria.
"The RAF jets used laser-guided Paveway IV weapons to target a several approach shafts leading to the facility... preliminary assessments suggest the objective was successfully hit," officials stated.
There was no evidence of any civilian casualties in the attack late on Saturday and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were backed up by a Voyager aerial refuelling aircraft.
Daesh - also known as ISIS - established jihadist rule over parts of Syria and Iraq prior to its 2019 collapse.
"This action demonstrates British leadership, and commitment to operate in unison with allied nations, to eliminate any revival of Daesh and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the minister remarked.
UK warplanes have carried out overwatch operations over Syrian airspace to "forestall any efforts to regroup" of Islamic State after its defeat at the battle of Baghuz in 2019, the MoD reported.
"I must thank every member of our armed forces who took part in this mission for their expertise and their bravery," he added. "They were part of numerous British personnel stationed over the festive period. This action, to eliminate dangerous terrorists who endanger our security, demonstrates how British military are ready to step up, all year round, keeping Britain secure at home and powerful internationally."
Last December, the American forces executed what it described as a "large-scale strike" against IS targets in Syria, following an assault resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations estimates Islamic State still maintains between 5,000 and 7,000 militants in both countries.